Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
Evidence
1:
Inferred from Physical InteractionUniProtKB
Pancreatic ductal adenocarcinoma (PDAC) shows one of the worst mortality rates among the common malignancies, and the great majority of PDAC patients are diagnosed at an advanced stage where no effective therapy is presently available. Hence, identification of novel molecular targets and development of molecular therapy for PDAC are urgently required. Through our genome-wide gene expression profiles of microdissected PDAC cells, we here identified a novel gene C2orf18 as a molecular target for PDAC treatment. Transcriptional and immunohistochemical analysis validated its overexpression in PDAC cells and limited expression in normal adult organs. Knockdown of C2orf18 by small-interfering RNA in PDAC cell lines resulted in induction of apoptosis and suppression of cancer cell growth, suggesting its essential role in maintaining viability of PDAC cells. We showed that C2orf18 was localized in the mitochondria and it could interact with adenine nucleotide translocase 2 (ANT2), which is involved in maintenance of the mitochondrial membrane potential and energy homeostasis, and was indicated some roles in apoptosis. These findings implicated that C2orf18, termed ANT2-binding protein (ANT2BP), might serve as a candidate molecular target for pancreatic cancer therapy.
Pancreatic ductal adenocarcinoma (PDAC) shows one of the worst mortality rates among the common malignancies, and the great majority of PDAC patients are diagnosed at an advanced stage where no effective therapy is presently available. Hence, identification of novel molecular targets and development of molecular therapy for PDAC are urgently required. Through our genome-wide gene expression profiles of microdissected PDAC cells, we here identified a novel gene C2orf18 as a molecular target for PDAC treatment. Transcriptional and immunohistochemical analysis validated its overexpression in PDAC cells and limited expression in normal adult organs. Knockdown of C2orf18 by small-interfering RNA in PDAC cell lines resulted in induction of apoptosis and suppression of cancer cell growth, suggesting its essential role in maintaining viability of PDAC cells. We showed that C2orf18 was localized in the mitochondria and it could interact with adenine nucleotide translocase 2 (ANT2), which is involved in maintenance of the mitochondrial membrane potential and energy homeostasis, and was indicated some roles in apoptosis. These findings implicated that C2orf18, termed ANT2-binding protein (ANT2BP), might serve as a candidate molecular target for pancreatic cancer therapy.
Pancreatic ductal adenocarcinoma (PDAC) shows one of the worst mortality rates among the common malignancies, and the great majority of PDAC patients are diagnosed at an advanced stage where no effective therapy is presently available. Hence, identification of novel molecular targets and development of molecular therapy for PDAC are urgently required. Through our genome-wide gene expression profiles of microdissected PDAC cells, we here identified a novel gene C2orf18 as a molecular target for PDAC treatment. Transcriptional and immunohistochemical analysis validated its overexpression in PDAC cells and limited expression in normal adult organs. Knockdown of C2orf18 by small-interfering RNA in PDAC cell lines resulted in induction of apoptosis and suppression of cancer cell growth, suggesting its essential role in maintaining viability of PDAC cells. We showed that C2orf18 was localized in the mitochondria and it could interact with adenine nucleotide translocase 2 (ANT2), which is involved in maintenance of the mitochondrial membrane potential and energy homeostasis, and was indicated some roles in apoptosis. These findings implicated that C2orf18, termed ANT2-binding protein (ANT2BP), might serve as a candidate molecular target for pancreatic cancer therapy.
A reference proteome is a set of protein sequences derived from a complete proteome which constitutes a defined standard for a particular user community. Reference proteomes are manually defined according to a number of criteria. They cover the proteomes of well- studied model organisms and other proteomes of interest for biomedical and biotechnological research. Reference proteomes have been selected to provide broad coverage of the tree of life, and constitute a representative cross-section of the taxonomic diversity to be found within UniProtKB.
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