ASCC3 - Activating signal cointegrator 1 complex subunit 3 - human protein (Function)
 
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Protein
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References

 
ASCC3 »  Activating signal cointegrator 1 complex subunit 3   [ EC 3.6.4.12 ]
 
Protein also known as:  Trip4 complex subunit p200.
Gene name:  ASCC3
Family name: Helicase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 38 3
GENE REF ISO

Function

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Overview 
3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Enhances NF-kappa-B, SRF and AP1 transactivation.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATP-dependent 3'-5' DNA helicase activitydefinition[GO:0043140]  
1
  • IDAUniProtKB
Nucleic acid bindingdefinition[GO:0003676] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • IDAGOC
Cell proliferationdefinition[GO:0008283]  
1
  • IMPUniProtKB
DNA dealkylation involved in DNA repairdefinition[GO:0006307]  
1
  • IDAUniProtKB
DNA duplex unwindingdefinition[GO:0032508]  
1
  • IDAUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.12: ATP + H(2)O ADP + phosphate.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ASCC3
GenomeRNAi: 10973
PRO: PR:Q8N3C0