VPS8 - Vacuolar protein sorting-associated protein 8 homolog - human protein (Function)
 
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VPS8 »  Vacuolar protein sorting-associated protein 8 homolog
 
Gene name:  VPS8
Family name: VPS8
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed25266290). Functions predominantly in APPL1-containing endosomes (PubMed25266290).  
3
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Endosomal vesicle fusiondefinition[GO:0034058]  
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  • UniProtKB
Protein transportdefinition[GO:0015031]  
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  • UniProtKB KW
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 23355
PRO: PR:Q8N3P4