LCORL - Ligand-dependent nuclear receptor corepressor-like protein - human protein (Function)
 
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LCORL »  Ligand-dependent nuclear receptor corepressor-like protein  (LCoR-like protein)
 
Gene name:  LCORL
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity).  
1
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357] silver  
1
  • Ortholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
1
  • Ortholog Compara
Caution 
A report observed N-glycosylation at Asn-493 (PubMed19139490). However, as the protein is predicted to act as a DNA-binding transcription activator, additional evidences are required to confirm this result.  
2
  • UniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 254251
PRO: PR:Q8N3X6