SFRP1 - Secreted frizzled-related protein 1 - human protein (Function)
 
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SFRP1 »  Secreted frizzled-related protein 1  (FRP-1)
 
Protein also known as:  Secreted apoptosis-related protein 2 (SARP-2).
Gene name:  SFRP1
Entry whose protein(s) existence is based on evidence at protein level
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1 126 1
GENE REF ISO

Function

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Overview 
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.  
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
1
  • IMPUniProtKB
Drug bindingdefinition[GO:0008144]  
2
  • IDAUniProtKB
Frizzled bindingdefinition[GO:0005109]  
3
  • IPIUniProtKB
  • IPIBHF-UCL
Heparin bindingdefinition[GO:0008201]  
3
  • IDAUniProtKB
  • IDABHF-UCL
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIBHF-UCL
PDZ domain bindingdefinition[GO:0030165] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Wnt-activated receptor activitydefinition[GO:0042813] silver  
  • IBARefGenome
Wnt-protein bindingdefinition[GO:0017147]  
3
  • IPIUniProtKB
  • IPIBHF-UCL
GO biological process 
Bone trabecula formationdefinition[GO:0060346] silver  
  • IEAOrtholog Compara
Brain developmentdefinition[GO:0007420] silver  
  • IBARefGenome
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
1
  • IDABHF-UCL
Cellular response to BMP stimulusdefinition[GO:0071773]  
1
  • IEPUniProtKB
Cellular response to estradiol stimulusdefinition[GO:0071392]  
1
  • IEPUniProtKB
Cellular response to estrogen stimulusdefinition[GO:0071391]  
1
  • IDAUniProtKB
Cellular response to fibroblast growth factor stimulusdefinition[GO:0044344]  
1
  • IDAUniProtKB
Cellular response to growth factor stimulusdefinition[GO:0071363]  
1
  • IDAUniProtKB
Cellular response to heparindefinition[GO:0071504]  
1
  • IDAUniProtKB
Cellular response to hypoxiadefinition[GO:0071456]  
1
  • IEPUniProtKB
Cellular response to interleukin-1definition[GO:0071347]  
1
  • IEPUniProtKB
Cellular response to prostaglandin E stimulusdefinition[GO:0071380]  
1
  • IEPUniProtKB
Cellular response to starvationdefinition[GO:0009267]  
2
  • IEPUniProtKB
Cellular response to transforming growth factor beta stimulusdefinition[GO:0071560]  
1
  • IEPUniProtKB
Cellular response to tumor necrosis factordefinition[GO:0071356]  
1
  • IDAUniProtKB
Cellular response to vitamin Ddefinition[GO:0071305]  
1
  • IEPUniProtKB
Cellular response to X-raydefinition[GO:0071481] silver  
  • IEAOrtholog Compara
Convergent extension involved in somitogenesisdefinition[GO:0090246] silver  
  • IEAOrtholog Compara
Digestive tract morphogenesisdefinition[GO:0048546] silver  
  • IEAOrtholog Compara
Dorsal/ventral axis specificationdefinition[GO:0009950]  
1
  • IDAUniProtKB
Female gonad developmentdefinition[GO:0008585] silver  
  • IEAOrtholog Compara
Gonad developmentdefinition[GO:0008406] silver  
  • IBARefGenome
Hematopoietic progenitor cell differentiationdefinition[GO:0002244]  
1
  • IDAUniProtKB
Hematopoietic stem cell differentiationdefinition[GO:0060218]  
1
  • IDAUniProtKB
Male gonad developmentdefinition[GO:0008584] silver  
  • IEAOrtholog Compara
Menstrual cycle phasedefinition[GO:0022601]  
1
  • IEPUniProtKB
Negative regulation of androgen receptor signaling pathwaydefinition[GO:0060766]  
1
  • IDAUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
5
  • IMPUniProtKB
Negative regulation of B cell differentiationdefinition[GO:0045578]  
1
  • IMPUniProtKB
Negative regulation of BMP signaling pathwaydefinition[GO:0030514] silver  
  • IEAOrtholog Compara
Negative regulation of bone remodelingdefinition[GO:0046851]  
1
  • IMPUniProtKB
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
12
  • IDAUniProtKB
  • IDABHF-UCL
Negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferationdefinition[GO:2000080]  
1
  • IDAUniProtKB
Negative regulation of cell growthdefinition[GO:0030308]  
2
  • IDAUniProtKB
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • IDAUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
5
  • IDAUniProtKB
  • IDABHF-UCL
Negative regulation of epithelial cell proliferationdefinition[GO:0050680]  
1
  • IDAUniProtKB
Negative regulation of epithelial to mesenchymal transitiondefinition[GO:0010719]  
1
  • IDAUniProtKB
Negative regulation of fibroblast apoptotic processdefinition[GO:2000270]  
1
  • IDAUniProtKB
Negative regulation of fibroblast proliferationdefinition[GO:0048147]  
1
  • IDABHF-UCL
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • IDAUniProtKB
Negative regulation of insulin secretiondefinition[GO:0046676]  
1
  • IDAUniProtKB
Negative regulation of JUN kinase activitydefinition[GO:0043508] silver  
  • IEAOrtholog Compara
Negative regulation of ossificationdefinition[GO:0030279]  
2
  • IMPUniProtKB
Negative regulation of osteoblast differentiationdefinition[GO:0045668] silver  
  • IEAOrtholog Compara
Negative regulation of osteoblast proliferationdefinition[GO:0033689]  
1
  • IMPUniProtKB
Negative regulation of osteoclast differentiationdefinition[GO:0045671] silver  
  • IEAOrtholog Compara
Negative regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050732]  
1
  • IDAUniProtKB
Negative regulation of planar cell polarity pathway involved in axis elongationdefinition[GO:2000041] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
5
  • IDAUniProtKB
Negative regulation of Wnt signaling pathwaydefinition[GO:0030178]  
5
  • IDAUniProtKB
Negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specificationdefinition[GO:2000054]  
1
  • IDAUniProtKB
Neural crest cell fate commitmentdefinition[GO:0014034] silver  
  • IEAOrtholog Compara
Neural tube closuredefinition[GO:0001843] silver  
  • IEAOrtholog Compara
Osteoblast differentiationdefinition[GO:0001649]  
1
  • IEPUniProtKB
Planar cell polarity pathway involved in neural tube closuredefinition[GO:0090179] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065]  
6
  • IMPUniProtKB
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
1
  • IDAUniProtKB
Positive regulation of cell growthdefinition[GO:0030307]  
2
  • IDAUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDAUniProtKB
Positive regulation of cell-matrix adhesiondefinition[GO:0001954]  
  • ISSOrtholog Curator
Positive regulation of epithelial cell proliferationdefinition[GO:0050679]  
1
  • IMPUniProtKB
Positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:1902043]  
1
  • IDABHF-UCL
Positive regulation of fat cell differentiationdefinition[GO:0045600]  
2
  • IDAUniProtKB
  • IDAMGI
Positive regulation of fibroblast apoptotic processdefinition[GO:2000271]  
1
  • IDAUniProtKB
Positive regulation of focal adhesion assemblydefinition[GO:0051894]  
  • ISSOrtholog Curator
Positive regulation of non-canonical Wnt signaling pathwaydefinition[GO:2000052]  
1
  • IDAUniProtKB
Positive regulation of Rac GTPase activitydefinition[GO:0032855]  
  • ISSOrtholog Curator
Positive regulation of smoothened signaling pathwaydefinition[GO:0045880]  
1
  • IMPUniProtKB
Positive regulation of stress fiber assemblydefinition[GO:0051496]  
  • ISSOrtholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
4
  • IDAUniProtKB
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177]  
1
  • IDAUniProtKB
Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisdefinition[GO:0060527] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
1
  • IMPGOC
Regulation of angiogenesisdefinition[GO:0045765]  
  • ISSOrtholog Curator
Regulation of branching involved in prostate gland morphogenesisdefinition[GO:0060687] silver  
  • IEAOrtholog Compara
Regulation of cell cycle processdefinition[GO:0010564]  
1
  • IMPUniProtKB
Response to drugdefinition[GO:0042493]  
2
  • IDAUniProtKB
Response to organic cyclic compounddefinition[GO:0014070]  
1
  • IDAUniProtKB
Somatic stem cell maintenancedefinition[GO:0035019] silver  
  • IEAOrtholog Compara
Stromal-epithelial cell signaling involved in prostate gland developmentdefinition[GO:0044345] silver  
  • IEAOrtholog Compara
Ureteric bud developmentdefinition[GO:0001657] silver  
  • IEAOrtholog Compara
Vasculature developmentdefinition[GO:0001944] silver  
  • IBARefGenome
Wnt signaling pathway involved in somitogenesisdefinition[GO:0090244] silver  
  • IEAOrtholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Wnt signaling pathway  hsa04310+6422  
According to Reactome, this protein belongs to the following pathway:
negative regulation of TCF-dependent signaling by WNT ligand antagonists  REACT_200643  
Note 
May have therapeutic use in cardiac surgery.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links