SFRP1 - Secreted frizzled-related protein 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
SFRP1 »  Secreted frizzled-related protein 1  (FRP-1)
 
Protein also known as:  Secreted apoptosis-related protein 2 (SARP-2).
Gene name:  SFRP1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 136 1
GENE REF ISO

Function

 show evidences
Overview 
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.  
1
  • UniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
1
  • UniProtKB
Drug bindingdefinition[GO:0008144]  
2
  • UniProtKB
Frizzled bindingdefinition[GO:0005109]  
3
  • UniProtKB
  • BHF-UCL
Not  G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • RefGenome
Heparin bindingdefinition[GO:0008201]  
3
  • UniProtKB
  • BHF-UCL
Identical protein bindingdefinition[GO:0042802]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Not  Wnt-activated receptor activitydefinition[GO:0042813]  
1
  • RefGenome
Wnt-protein bindingdefinition[GO:0017147]  
3
  • UniProtKB
  • BHF-UCL
GO biological process 
Bone trabecula formationdefinition[GO:0060346] silver  
1
  • Ortholog Compara
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
1
  • BHF-UCL
Cellular response to BMP stimulusdefinition[GO:0071773]  
1
  • UniProtKB
Cellular response to estradiol stimulusdefinition[GO:0071392]  
1
  • UniProtKB
Cellular response to estrogen stimulusdefinition[GO:0071391]  
1
  • UniProtKB
Cellular response to fibroblast growth factor stimulusdefinition[GO:0044344]  
1
  • UniProtKB
Cellular response to growth factor stimulusdefinition[GO:0071363]  
1
  • UniProtKB
Cellular response to heparindefinition[GO:0071504]  
1
  • UniProtKB
Cellular response to hypoxiadefinition[GO:0071456]  
1
  • UniProtKB
Cellular response to interleukin-1definition[GO:0071347]  
1
  • UniProtKB
Cellular response to prostaglandin E stimulusdefinition[GO:0071380]  
1
  • UniProtKB
Cellular response to starvationdefinition[GO:0009267]  
2
  • UniProtKB
Cellular response to transforming growth factor beta stimulusdefinition[GO:0071560]  
1
  • UniProtKB
Cellular response to tumor necrosis factordefinition[GO:0071356]  
1
  • UniProtKB
Cellular response to vitamin Ddefinition[GO:0071305]  
1
  • UniProtKB
Cellular response to X-raydefinition[GO:0071481] silver  
1
  • Ortholog Compara
Convergent extension involved in somitogenesisdefinition[GO:0090246] silver  
1
  • Ortholog Compara
Digestive tract morphogenesisdefinition[GO:0048546] silver  
1
  • Ortholog Compara
Dorsal/ventral axis specificationdefinition[GO:0009950]  
1
  • UniProtKB
Female gonad developmentdefinition[GO:0008585] silver  
1
  • Ortholog Compara
Hematopoietic progenitor cell differentiationdefinition[GO:0002244]  
1
  • UniProtKB
Hematopoietic stem cell differentiationdefinition[GO:0060218]  
1
  • UniProtKB
Male gonad developmentdefinition[GO:0008584] silver  
1
  • Ortholog Compara
Menstrual cycle phasedefinition[GO:0022601]  
1
  • UniProtKB
Negative regulation of androgen receptor signaling pathwaydefinition[GO:0060766]  
1
  • UniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
5
  • UniProtKB
Negative regulation of B cell differentiationdefinition[GO:0045578]  
1
  • UniProtKB
Negative regulation of BMP signaling pathwaydefinition[GO:0030514] silver  
1
  • Ortholog Compara
Negative regulation of bone remodelingdefinition[GO:0046851]  
1
  • UniProtKB
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
12
  • UniProtKB
  • BHF-UCL
Negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferationdefinition[GO:2000080]  
1
  • UniProtKB
Negative regulation of cell growthdefinition[GO:0030308]  
2
  • UniProtKB
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • UniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
5
  • UniProtKB
  • BHF-UCL
Negative regulation of epithelial cell proliferationdefinition[GO:0050680]  
1
  • UniProtKB
Negative regulation of epithelial to mesenchymal transitiondefinition[GO:0010719]  
1
  • UniProtKB
Negative regulation of fibroblast apoptotic processdefinition[GO:2000270]  
1
  • UniProtKB
Negative regulation of fibroblast proliferationdefinition[GO:0048147]  
1
  • BHF-UCL
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • UniProtKB
Negative regulation of insulin secretiondefinition[GO:0046676]  
1
  • UniProtKB
Negative regulation of JUN kinase activitydefinition[GO:0043508] silver  
1
  • Ortholog Compara
Negative regulation of ossificationdefinition[GO:0030279]  
2
  • UniProtKB
Negative regulation of osteoblast differentiationdefinition[GO:0045668] silver  
1
  • Ortholog Compara
Negative regulation of osteoblast proliferationdefinition[GO:0033689]  
1
  • UniProtKB
Negative regulation of osteoclast differentiationdefinition[GO:0045671] silver  
1
  • Ortholog Compara
Negative regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050732]  
1
  • UniProtKB
Negative regulation of planar cell polarity pathway involved in axis elongationdefinition[GO:2000041] silver  
1
  • Ortholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
5
  • UniProtKB
Negative regulation of Wnt signaling pathwaydefinition[GO:0030178]  
5
  • UniProtKB
Negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specificationdefinition[GO:2000054]  
1
  • UniProtKB
Neural crest cell fate commitmentdefinition[GO:0014034] silver  
1
  • Ortholog Compara
Neural tube closuredefinition[GO:0001843] silver  
1
  • Ortholog Compara
Osteoblast differentiationdefinition[GO:0001649]  
1
  • UniProtKB
Planar cell polarity pathway involved in neural tube closuredefinition[GO:0090179] silver  
1
  • Ortholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065]  
6
  • UniProtKB
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
1
  • UniProtKB
Positive regulation of cell growthdefinition[GO:0030307]  
2
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • UniProtKB
Positive regulation of cell-matrix adhesiondefinition[GO:0001954]  
1
  • Ortholog Curator
Positive regulation of epithelial cell proliferationdefinition[GO:0050679]  
1
  • UniProtKB
Positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:1902043]  
1
  • BHF-UCL
Positive regulation of fat cell differentiationdefinition[GO:0045600]  
2
  • UniProtKB
  • MGI
Positive regulation of fibroblast apoptotic processdefinition[GO:2000271]  
1
  • UniProtKB
Positive regulation of focal adhesion assemblydefinition[GO:0051894]  
1
  • Ortholog Curator
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • Ortholog Curator
Positive regulation of non-canonical Wnt signaling pathwaydefinition[GO:2000052]  
1
  • UniProtKB
Positive regulation of smoothened signaling pathwaydefinition[GO:0045880]  
1
  • UniProtKB
Positive regulation of stress fiber assemblydefinition[GO:0051496]  
1
  • Ortholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
4
  • UniProtKB
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177]  
1
  • UniProtKB
Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisdefinition[GO:0060527] silver  
1
  • Ortholog Compara
Proteolysisdefinition[GO:0006508]  
1
  • GOC
Regulation of angiogenesisdefinition[GO:0045765]  
1
  • Ortholog Curator
Regulation of branching involved in prostate gland morphogenesisdefinition[GO:0060687] silver  
1
  • Ortholog Compara
Regulation of cell cycle processdefinition[GO:0010564]  
1
  • UniProtKB
Response to drugdefinition[GO:0042493]  
2
  • UniProtKB
Response to organic cyclic compounddefinition[GO:0014070]  
1
  • UniProtKB
Somatic stem cell maintenancedefinition[GO:0035019] silver  
1
  • Ortholog Compara
Stromal-epithelial cell signaling involved in prostate gland developmentdefinition[GO:0044345] silver  
1
  • Ortholog Compara
Ureteric bud developmentdefinition[GO:0001657] silver  
1
  • Ortholog Compara
Wnt signaling pathway involved in somitogenesisdefinition[GO:0090244] silver  
1
  • Ortholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Wnt signaling pathway  hsa04310+6422  
According to Reactome, this protein belongs to the following pathway:
negative regulation of TCF-dependent signaling by WNT ligand antagonists  REACT_264383  
Note 
May have therapeutic use in cardiac surgery.  
1
  • UniProtKB
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links