MINK1 - Misshapen-like kinase 1 - human protein (Function)
 
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Protein
Gene
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MINK1 »  Misshapen-like kinase 1   [ EC 2.7.11.1 ]
 
Protein also known as:  Mitogen-activated protein kinase kinase kinase kinase 6.
Gene name:  MINK1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 5
GENE REF ISO

Function

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Overview 
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.  
1
  • UniProtKB
Isoform  Iso 4   Can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.  
1
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Protein kinase activitydefinition[GO:0004672]  
1
  • PINC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • UniProtKB
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702]  
1
  • RefGenome
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • UniProtKB
Dendrite morphogenesisdefinition[GO:0048813]  
1
  • Ortholog Curator
Intracellular signal transductiondefinition[GO:0035556]  
1
  • Ortholog Curator
JNK cascadedefinition[GO:0007254]  
1
  • PINC
Not  Microvillus assemblydefinition[GO:0030033]  
1
  • UniProtKB
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • Ortholog Curator
Negative thymic T cell selectiondefinition[GO:0045060] silver  
1
  • Ortholog Compara
Positive regulation of JNK cascadedefinition[GO:0046330]  
1
  • UniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468]  
2
  • CACAO
  • Ortholog Curator
Regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activitydefinition[GO:2000311]  
1
  • Ortholog Curator
Regulation of cell migrationdefinition[GO:0030334]  
1
  • UniProtKB
Regulation of cell-cell adhesiondefinition[GO:0022407]  
1
  • UniProtKB
Regulation of cell-matrix adhesiondefinition[GO:0001952]  
1
  • UniProtKB
Response to stressdefinition[GO:0006950]  
1
  • Ortholog Curator
Synaptic transmissiondefinition[GO:0007268]  
1
  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
2
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
2
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Oxidative Stress Induced Senescence  REACT_169436  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MINK1
GenomeRNAi: 50488
PRO: PR:Q8N4C8
Chemistry
GuidetoPHARMACOLOGY: 2103