DCLK2 - Serine/threonine-protein kinase DCLK2 - human protein (Function)
 
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DCLK2 »  Serine/threonine-protein kinase DCLK2   [ EC 2.7.11.1 ]
 
Protein also known as:  Doublecortin domain-containing protein 3B.
Gene name:  DCLK2
Entry whose protein(s) existence is based on evidence at protein level
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1 19 3
GENE REF ISO

Function

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Overview 
Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
GO biological process 
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 166614
PRO: PR:Q8N568
Chemistry
GuidetoPHARMACOLOGY: 2006