CERS5 - Ceramide synthase 5 - human protein (Function)
 
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Protein
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References

 
CERS5 »  Ceramide synthase 5   [ EC 2.3.1.24 ]  (CerS5)
 
Protein also known as:  LAG1 longevity assurance homolog 5.
Gene name:  CERS5
Entry whose protein(s) existence is based on evidence at protein level
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1 15 2
GENE REF ISO

Function

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Overview 
Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1 (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
Sphingosine N-acyltransferase activitydefinition[GO:0050291]  
1
  • IDAHGNC
GO biological process 
Ceramide biosynthetic processdefinition[GO:0046513]  
1
  • IDAHGNC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.24: Acyl-CoA + sphingosine CoA + N-acylsphingosine.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Sphingolipid metabolism  definition   [KW-0746]
Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 91012
PRO: PR:Q8N5B7