CISD2 - CDGSH iron-sulfur domain-containing protein 2 - human protein (Function)
 
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CISD2 »  CDGSH iron-sulfur domain-containing protein 2
 
Protein also known as:  Endoplasmic reticulum intermembrane small protein.
Gene name:  CISD2
Family name: CISD protein » CISD2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.  
3
  • UniProtKB
GO molecular function 
2 iron, 2 sulfur cluster bindingdefinition[GO:0051537]  
1
  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
GO biological process 
Mitochondrion degradationdefinition[GO:0000422] silver  
1
  • Ortholog Compara
Multicellular organismal agingdefinition[GO:0010259]  
1
  • Ortholog Curator
Regulation of autophagydefinition[GO:0010506]  
1
  • UniProtKB
Enzymatic activity 
It requires the following cofactor
 [2Fe-2S] cluster : Binds 1 [2Fe-2S] cluster.  
2
  • UniProtKB
Caution 
Although initially thought (PubMed17846994) to be a zinc-finger protein, it was later shown (PubMed17376863) that it binds 1 2Fe-2S cluster instead.  
3
  • UniProtKB
 

Biophysicochemical properties

Redox potential
E is 0 +/- 10 mV for 2Fe-2S at pH 7.5.

Keywords

Biological process 
Autophagy  definition   [KW-0072]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 493856
PRO: PR:Q8N5K1