ARFGAP2 - ADP-ribosylation factor GTPase-activating protein 2 - human protein (Function)
 
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ARFGAP2 »  ADP-ribosylation factor GTPase-activating protein 2
 
Gene name:  ARFGAP2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.  
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  • CuratedUniProtKB
GO molecular function 
ARF GTPase activator activitydefinition[GO:0008060] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Positive regulation of GTPase activitydefinition[GO:0043547]  
  • IEAInterPro 2 GO
  • IEAUniProtKB KW
Protein transportdefinition[GO:0015031]  
  • IEAUniProtKB KW
Regulation of ARF GTPase activitydefinition[GO:0032312] silver  
  • IEAInterPro 2 GO
Vesicle-mediated transportdefinition[GO:0016192]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Endocytosis  hsa04144+84364  
Note 
Vero cells overexpressing truncated ARFGAP2 show accumulation of cholera toxin A subunit in the Golgi complex rather than the endoplasmic reticulum.  
  • CuratedUniProtKB
 

Keywords

Biological process 
ER-Golgi transport  definition   [KW-0931]
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Molecular function 
GTPase activation  definition   [KW-0343]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 84364
PRO: PR:Q8N6H7