AOPEP - Aminopeptidase O - human protein (Function)
 
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AOPEP »  Aminopeptidase O   [ EC 3.4.11.- ]  (AP-O)
 
Gene name:  AOPEP
Family name: Peptidase M1
Entry whose protein(s) existence is based on evidence at protein level
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1 17 4
GENE REF ISO

Function

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Overview 
Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.  
1
  • CuratedUniProtKB
GO molecular function 
Aminopeptidase activitydefinition[GO:0004177]  
1
  • IDAMGI
Metallopeptidase activitydefinition[GO:0008237]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Leukotriene biosynthetic processdefinition[GO:0019370] silver  
  • IEAInterPro 2 GO
Proteolysisdefinition[GO:0006508]  
1
  • IDAMGI
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Strongly inhibited by ophenanthroline, a metalloprotease inhibitor. Inhibited by arphamenine A, a potent inhibitor of aminopeptidases. Not affected by AEBSF and E-64, which are common inhibitors of serine- and cysteine-proteases, respectively.  
1
  • CuratedUniProtKB
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 6 uM for Arg-AMC

Keywords

Molecular function 
Aminopeptidase  definition   [KW-0031]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q8N6M6
Other
GenomeRNAi: 84909
PRO: PR:Q8N6M6