ENAH - Protein enabled homolog - human protein (Function)
 
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Protein
Gene
References

 
ENAH »  Protein enabled homolog
 
Gene name:  ENAH
Family name: Ena/VASP
Entry whose protein(s) existence is based on evidence at protein level
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1 52 3
GENE REF ISO

Function

 show evidences
Overview 
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity).  
2
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
SH3 domain bindingdefinition[GO:0017124] silver  
  • IEAOrtholog Compara
WW domain bindingdefinition[GO:0050699]  
1
  • IPIUniProtKB
GO biological process 
Actin polymerization or depolymerizationdefinition[GO:0008154] silver  
  • IEAOrtholog Compara
Intracellular transportdefinition[GO:0046907] silver  
  • IEAInterPro 2 GO
Neural tube closuredefinition[GO:0001843] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Regulation of actin cytoskeleton  hsa04810+55740  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Immune System  REACT_6900  
Note 
Required to transform actin polymerization into active movement for the propulsive force of Listeria monocytogenes (By similarity).  
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ENAH_(gene)
GenomeRNAi: 55740
PRO: PR:Q8N8S7