MFSD2A - Sodium-dependent lysophosphatidylcholine symporter 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
MFSD2A »  Sodium-dependent lysophosphatidylcholine symporter 1  (NLS1)
 
Protein also known as:  Major facilitator superfamily domain-containing protein 2A.
Gene name:  MFSD2A
Family name: Major facilitator
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 3
GENE REF ISO

Function

 show evidences
Overview 
Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport. Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion (PubMed18988732).  
3
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the glycoside-pentoside-hexuronide (gph):cation symporter family  2.A.2.3.8  
GO molecular function 
Phospholipid transporter activitydefinition[GO:0005548]  
  • ISSOrtholog Curator
Symporter activitydefinition[GO:0015293]  
  • ISSOrtholog Curator
GO biological process 
Establishment of blood-brain barrierdefinition[GO:0060856]  
  • ISSOrtholog Curator
Fatty acid transportdefinition[GO:0015908]  
  • ISSOrtholog Curator
Lipid transport across blood brain barrierdefinition[GO:1990379]  
  • ISSOrtholog Curator
Phospholipid transportdefinition[GO:0015914]  
  • ISSOrtholog Curator
Transcytosisdefinition[GO:0045056]  
  • ISSOrtholog Curator
Transmembrane transportdefinition[GO:0055085]  
  • IEAUniProtKB KW
  • ISSOrtholog Curator
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MFSD2
GenomeRNAi: 84879
PRO: PR:Q8NA29