FNDC5 - Fibronectin type III domain-containing protein 5 - human protein (Function)
 
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Protein
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FNDC5 »  Fibronectin type III domain-containing protein 5
 
Cleaved into:  Irisin.
Gene name:  FNDC5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue (PubMed24040023).  
1
  • CuratedUniProtKB
GO molecular function 
Hormone activitydefinition[GO:0005179]  
  • IEAUniProtKB KW
GO biological process 
Positive regulation of brown fat cell differentiationdefinition[GO:0090336]  
  • ISSOrtholog Curator
Response to muscle activitydefinition[GO:0014850]  
  • ISSOrtholog Curator
 

Keywords

Molecular function 
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 252995
PRO: PR:Q8NAU1