FNDC5 - Fibronectin type III domain-containing protein 5 - human protein (Sequence)
 
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FNDC5 »  Fibronectin type III domain-containing protein 5
 
Protein also known as:  Fibronectin type III repeat-containing protein 2. Cleaved into:  Irisin.
Gene name:  FNDC5
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 4
GENE REF ISO

Displayed isoform: Iso 1     

 
 
Isoform Iso 1   212 aaMass: 23659 Da,  pI: 6.91
MHPGSPSAWP PRARAALRLW LGCVCFALVQ ADSPSAPVNV TVRHLKANSA VVSWDVLEDE VVIGFAISQQ KKDVRMLRFI QEVNTTTRSC ALWDLEEDTE YIVHVQAISI QGQSPASEPV LFKTPREAEK MASKNKDEVT MKEMGRNQQL RTGEVLIIVV VLFMWAGVIA LFCRQYDIIK DNEPNNNKEK TKSASETSTP EHQGGGLLRS KI

Sequence

 show evidences
PTM 
The extracellular domain is cleaved and released from the cell membrane.  
  • CuratedUniProtKB
N-Glycosylated (By similarity).  
  • CuratedUniProtKB
Caution 
It is uncertain whether Met-1 or Met-76 is the initiator. Transcript evidence available at present time points at Met-76. In this short version of the protein, the signal peptide cannot be predicted and the irisin peptide is severely truncated. The first initiation codon corresponds to a non-AUG site, an N-terminal ATA codon. This initiation codon has been annotated as it is in good Kozak context and it is conserved in other primates, including gibbon, chimpanzee and gorilla. Although the existence of such a form has not been demonstrated in human, western blot analysis following endurance exercise shows the presence of an irisin peptide of similar size in human and mouse plasma (PubMed22237023), suggesting the existence of full length irisin in human, at least in some tissues. However, expression from Met-1 may be less efficient than that from Met-76 (PubMed24040023).  
2
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Alternative splicing  definition   [KW-0025]
Domain 
Signal  definition   [KW-0732]
Transmembrane  definition   [KW-0812]
Transmembrane helix  definition   [KW-1133]
PTM 
Glycoprotein  definition   [KW-0325]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 2.60.40.10
InterPro: IPR003961 [ Fibronectin type3 ]
InterPro: IPR013783 [ Ig-like fold ]
Pfam: PF00041 [ fn3 ]
PROSITE: PS50853 [ FN3 ]
SMART: SM00060 [ FN3 ]
SUPFAM: SSF49265 [ SSF49265 ]
Genome annotation databases
Ensembl: Transcript: ENST00000373471;  Protein: ENSP00000362570;  Gene: ENSG00000160097.
Ensembl: Transcript: ENST00000496770;  Protein: ENSP00000476320;  Gene: ENSG00000160097.
Ensembl: Transcript: ENST00000609187;  Protein: ENSP00000476668;  Gene: ENSG00000160097.
KEGG: hsa:252995
UCSC: uc001bwf.2
UCSC: uc001bwg.3
Organism-specific databases
MGI: MGI:1917614 [ Fndc5 ]
PTM databases
PhosphoSite: Q8NAU1
Phylogenomic databases
eggNOG: NOG87775
HOGENOM: HOG000082536
HOVERGEN: HBG067308
InParanoid: Q8NAU1
OMA: PDENGME
OrthoDB: EOG7S2206
Sequence databases
CCDS: CCDS369.2 [ Q8NAU1-1 ]
CCDS: CCDS65483.1 [ Q8NAU1-3 ]
CCDS: CCDS369.1 [ Q8NAU1-4 ]
EMBL: Genomic DNA:  AC114493 . No translation available.
EMBL: Genomic DNA:  CH471059 . Translation:  EAX07499.1 .
EMBL: Genomic DNA:  CH471059 . Translation:  EAX07502.1 .
EMBL: mRNA:  AK092102 . Translation:  BAC03806.1 .
EMBL: mRNA:  BX537781 . Translation:  CAD97840.1 .
EMBL: mRNA:  BC062297 . Translation:  AAH62297.1 .
EMBL: Genomic DNA:  CH471059 . Translation:  EAX07500.1 .
EMBL: mRNA:  BF221649 . No translation available.
IPI: IPI00854598
IPI: IPI00889652
IPI: IPI00385341
IPI: IPI00514152
RefSeq: Protein:  NP_001165411.2. Nucleotide sequence:  NM_001171940.1.
RefSeq: Protein:  NP_001165412.1. Nucleotide sequence:  NM_001171941.2.
RefSeq: Protein:  NP_715637.2. Nucleotide sequence:  NM_153756.2.
UniProtKB: Q8NAU1
Protocols and materials databases
DNASU: 252995