ATAD1 - ATPase family AAA domain-containing protein 1 - human protein (Function)
 
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ATAD1 »  ATPase family AAA domain-containing protein 1   [ EC 3.6.1.3 ]
 
Protein also known as:  Thorase.
Gene name:  ATAD1
Family name: AAA ATPase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activitydefinition[GO:0016887]  
  • ISSOrtholog Curator
GO biological process 
Learningdefinition[GO:0007612]  
  • ISSOrtholog Curator
Memorydefinition[GO:0007613]  
  • ISSOrtholog Curator
Negative regulation of synaptic transmission, glutamatergicdefinition[GO:0051967]  
  • ISSOrtholog Curator
Positive regulation of receptor internalizationdefinition[GO:0002092]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.1.3: ATP + H(2)O ADP + phosphate.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 84896
PRO: PR:Q8NBU5