SLC38A9 - Sodium-coupled neutral amino acid transporter 9 - human protein (Function)
 
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Protein
Gene
References

 
SLC38A9 »  Sodium-coupled neutral amino acid transporter 9
 
Protein also known as:  Solute carrier family 38 member 9.
Gene name:  SLC38A9
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acids. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed25561175, PubMed25567906). Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids, suggesting that it acts as an amino acid sensor instead (PubMed25561175, PubMed25567906). The high concentration of arginine in lysosomes suggests that it acts as an arginine sensor (PubMed25567906).  
3
  • UniProtKB
According to TCDB this is a transporter from family:
the amino acid/auxin permease (aaap) family  2.A.18.9.1  
GO molecular function 
Amino acid transmembrane transporter activitydefinition[GO:0015171]  
3
  • UniProtKB
  • RefGenome
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Amino acid transmembrane transportdefinition[GO:0003333]  
2
  • UniProtKB
  • RefGenome
Cellular response to amino acid stimulusdefinition[GO:0071230]  
2
  • UniProtKB
Positive regulation of TOR signalingdefinition[GO:0032008]  
2
  • UniProtKB
 

Keywords

Biological process 
Amino-acid transport  definition   [KW-0029]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 153129
PRO: PR:Q8NBW4