DYNC2H1 - Cytoplasmic dynein 2 heavy chain 1 - human protein (Function)
 
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DYNC2H1 »  Cytoplasmic dynein 2 heavy chain 1
 
Protein also known as:  Cytoplasmic dynein 2 heavy chain.
Gene name:  DYNC2H1
Family name: Dynein heavy chain
Entry whose protein(s) existence is based on evidence at protein level
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1 40 3
GENE REF ISO

Function

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Overview 
May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity).  
1
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
ATPase activitydefinition[GO:0016887] silver  
1
  • InterPro 2 GO
Microtubule motor activitydefinition[GO:0003777] silver  
1
  • InterPro 2 GO
Motor activitydefinition[GO:0003774]  
1
  • UniProtKB
GO biological process 
Asymmetric protein localizationdefinition[GO:0008105] silver  
1
  • Ortholog Compara
ATP catabolic processdefinition[GO:0006200]  
1
  • InterPro 2 GO
Cilium assemblydefinition[GO:0042384] silver  
1
  • Ortholog Compara
Determination of left/right symmetrydefinition[GO:0007368] silver  
1
  • Ortholog Compara
Dorsal/ventral pattern formationdefinition[GO:0009953] silver  
1
  • Ortholog Compara
Embryonic limb morphogenesisdefinition[GO:0030326] silver  
1
  • Ortholog Compara
Forebrain developmentdefinition[GO:0030900] silver  
1
  • Ortholog Compara
Golgi organizationdefinition[GO:0007030]  
1
  • UniProtKB
Intraciliary retrograde transportdefinition[GO:0035721] silver  
1
  • Ortholog Compara
Positive regulation of smoothened signaling pathwaydefinition[GO:0045880] silver  
1
  • Ortholog Compara
Protein processingdefinition[GO:0016485] silver  
1
  • Ortholog Compara
Spinal cord motor neuron differentiationdefinition[GO:0021522] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Phagosome  hsa04145+79659  
Salmonella infection  hsa05132+79659  
Vasopressin-regulated water reabsorption  hsa04962+79659  
According to Reactome, this protein belongs to the following pathways:
Hedgehog 'off' state  REACT_267634  
MHC class II antigen presentation  REACT_121399  
 

Keywords

Biological process 
Cilium biogenesis/degradation  definition   [KW-0970]
Molecular function 
Developmental protein  definition   [KW-0217]
Motor protein  definition   [KW-0505]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DYNC2H1
GenomeRNAi: 79659
PRO: PR:Q8NCM8