ZNRF1 - E3 ubiquitin-protein ligase ZNRF1 - human protein (Function)
 
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Protein
Gene
References

 
ZNRF1 »  E3 ubiquitin-protein ligase ZNRF1   [ EC 6.3.2.- ]
 
Protein also known as:  Nerve injury-induced gene 283 protein.
Gene name:  ZNRF1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 12 2
GENE REF ISO

Function

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Overview 
E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Ubiquitin-protein ligase activitydefinition[GO:0004842]  
  • ISSOrtholog Curator
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Proteasome-mediated ubiquitin-dependent protein catabolic processdefinition[GO:0043161]  
  • ISSOrtholog Curator
Protein K48-linked ubiquitinationdefinition[GO:0070936]  
  • ISSOrtholog Curator
Pathways 
This protein is involved in the following pathway
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ZNRF1
GenomeRNAi: 84937
PRO: PR:Q8ND25