AGBL5 - Cytosolic carboxypeptidase-like protein 5 - human protein (Function)
 
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AGBL5 »  Cytosolic carboxypeptidase-like protein 5   [ EC 3.4.17.- ]
 
Protein also known as:  ATP/GTP-binding protein-like 5.
Gene name:  AGBL5
Family name: Peptidase M14
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6.  
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  • UniProtKB
GO molecular function 
Metallocarboxypeptidase activitydefinition[GO:0004181]  
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  • Ortholog Curator
Tubulin bindingdefinition[GO:0015631]  
1
  • Ortholog Curator
Zinc ion bindingdefinition[GO:0008270] silver  
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  • InterPro 2 GO
GO biological process 
Protein branching point deglutamylationdefinition[GO:0035611]  
1
  • Ortholog Curator
Protein deglutamylationdefinition[GO:0035608]  
1
  • Ortholog Curator
Proteolysisdefinition[GO:0006508]  
1
  • UniProtKB KW
Enzymatic activity 
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion per subunit.  
1
  • UniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Carboxypeptidase  definition   [KW-0121]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 60509
PRO: PR:Q8NDL9