HIPK4 - Homeodomain-interacting protein kinase 4 - human protein (Function)
 
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HIPK4 »  Homeodomain-interacting protein kinase 4   [ EC 2.7.11.1 ]
 
Gene name:  HIPK4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential).  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • UniProtKB KW
GO biological process 
Histone phosphorylationdefinition[GO:0016572] silver  
1
  • Ortholog Compara
Peptidyl-serine phosphorylationdefinition[GO:0018105] silver  
1
  • Ortholog Compara
Protein autophosphorylationdefinition[GO:0046777] silver  
1
  • Ortholog Compara
Regulation of signal transduction by p53 class mediatordefinition[GO:1901796] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 147746
PRO: PR:Q8NE63
Chemistry
GuidetoPHARMACOLOGY: 2036