BVES - Blood vessel epicardial substance - human protein (Function)
 
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BVES »  Blood vessel epicardial substance
 
Protein also known as:  Popeye domain-containing protein 1 (Popeye protein 1).
Gene name:  BVES
Family name: Popeye
Entry whose protein(s) existence is based on evidence at protein level
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1 22 1
GENE REF ISO

Function

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Overview 
Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading.  
2
  • CuratedUniProtKB
GO molecular function 
Structural molecule activitydefinition[GO:0005198]  
1
  • IDAUniProtKB
GO biological process 
Epithelial cell-cell adhesiondefinition[GO:0090136]  
1
  • IDAUniProtKB
Muscle organ developmentdefinition[GO:0007517]  
1
  • NASUniProtKB
Positive regulation of locomotiondefinition[GO:0040017]  
  • ISSOrtholog Curator
Positive regulation of receptor recyclingdefinition[GO:0001921]  
  • ISSOrtholog Curator
Regulation of Cdc42 GTPase activitydefinition[GO:0043088]  
  • ISSOrtholog Curator
Regulation of cell shapedefinition[GO:0008360]  
  • ISSOrtholog Curator
Regulation of Rac GTPase activitydefinition[GO:0032314]  
  • ISSOrtholog Curator
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446]  
  • ISSOrtholog Curator
Vesicle-mediated transportdefinition[GO:0016192]  
  • ISSOrtholog Curator
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links