MCU - Calcium uniporter protein, mitochondrial - human protein (Function)
 
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MCU »  Calcium uniporter protein, mitochondrial
 
Protein also known as:  Coiled-coil domain-containing protein 109A.
Gene name:  MCU
Family name: MCU
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes.  
9
  • CuratedUniProtKB
GO molecular function 
Calcium channel activitydefinition[GO:0005262]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
Uniporter activitydefinition[GO:0015292]  
3
  • IDAUniProtKB
GO biological process 
Calcium-mediated signalingdefinition[GO:0019722]  
2
  • IDAUniProtKB
Glucose homeostasisdefinition[GO:0042593]  
1
  • IMPUniProtKB
Mitochondrial calcium ion transportdefinition[GO:0006851]  
3
  • IDAUniProtKB
Positive regulation of insulin secretiondefinition[GO:0032024]  
1
  • IMPUniProtKB
Positive regulation of mitochondrial calcium ion concentrationdefinition[GO:0051561]  
3
  • IDAUniProtKB
Protein complex oligomerizationdefinition[GO:0035786]  
1
  • IDAUniProtKB
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 90550
PRO: PR:Q8NE86