CATSPER1 - Cation channel sperm-associated protein 1 - human protein (Function)
 
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CATSPER1 »  Cation channel sperm-associated protein 1  (CatSper1)
 
Gene name:  CATSPER1
Entry whose protein(s) existence is based on evidence at protein level
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1 35 1
GENE REF ISO

Function

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Overview 
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.19.1  
GO molecular function 
Calcium activated cation channel activitydefinition[GO:0005227] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Voltage-gated calcium channel activitydefinition[GO:0005245] silver  
  • IBARefGenome
GO biological process 
Calcium ion importdefinition[GO:0070509] silver  
  • IBARefGenome
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Cilium or flagellum-dependent cell motilitydefinition[GO:0001539] silver  
  • IEAOrtholog Compara
Fusion of sperm to egg plasma membranedefinition[GO:0007342] silver  
  • IEAOrtholog Compara
Membrane depolarization during action potentialdefinition[GO:0086010] silver  
  • IBARefGenome
Multicellular organismal developmentdefinition[GO:0007275]  
  • IEAUniProtKB KW
Regulation of calcium ion transportdefinition[GO:0051924] silver  
  • IEAOrtholog Compara
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Sperm motilitydefinition[GO:0030317] silver  
  • IBARefGenome
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Sperm Motility And Taxes  REACT_163875  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Differentiation  definition   [KW-0221]
Ion transport  definition   [KW-0406]
Spermatogenesis  definition   [KW-0744]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Developmental protein  definition   [KW-0217]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CatSper1
GenomeRNAi: 117144
PRO: PR:Q8NEC5
Chemistry
GuidetoPHARMACOLOGY: 388