AGBL3 - Cytosolic carboxypeptidase 3 - human protein (Function)
 
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AGBL3 »  Cytosolic carboxypeptidase 3   [ EC 3.4.17.- ]
 
Protein also known as:  ATP/GTP-binding protein-like 3.
Gene name:  AGBL3
Family name: Peptidase M14
Entry whose protein(s) existence is based on evidence at transcript level
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GENE REF ISO

Function

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Overview 
Metallocarboxypeptidase that mediates both deglutamylation and deaspartylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates or polyaspartates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.  
2
  • UniProtKB
GO molecular function 
Metallocarboxypeptidase activitydefinition[GO:0004181]  
2
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
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  • InterPro 2 GO
GO biological process 
Isoform  Iso 2   Protein side chain deglutamylationdefinition[GO:0035610]  
1
  • UniProtKB
Proteolysisdefinition[GO:0006508]  
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  • GOC
  • UniProtKB KW
Enzymatic activity 
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion per subunit.  
1
  • UniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Carboxypeptidase  definition   [KW-0121]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 340351
PRO: PR:Q8NEM8