TRPV1 - Transient receptor potential cation channel subfamily V member 1 - human protein (Function)
 
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TRPV1 »  Transient receptor potential cation channel subfamily V member 1
 
Gene name:  TRPV1
Entry whose protein(s) existence is based on evidence at protein level
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1 196 1
GENE REF ISO

Function

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Overview 
Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity). Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel.  
4
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • ISSOrtholog Curator
Calcium channel activitydefinition[GO:0005262]  
1
  • TASPINC
Calcium-release channel activitydefinition[GO:0015278]  
  • ISSOrtholog Curator
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Excitatory extracellular ligand-gated ion channel activitydefinition[GO:0005231]  
  • ISSOrtholog Curator
Phosphoprotein bindingdefinition[GO:0051219]  
1
  • IPIUniProtKB
Transmembrane signaling receptor activitydefinition[GO:0004888]  
  • ISSOrtholog Curator
GO biological process 
Calcium ion transmembrane transportdefinition[GO:0070588]  
  • ISSOrtholog Curator
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Cellular response to alkaloiddefinition[GO:0071312]  
  • ISSOrtholog Curator
Cellular response to ATPdefinition[GO:0071318]  
  • ISSOrtholog Curator
Chemosensory behaviordefinition[GO:0007635]  
1
  • TASPINC
Thermoceptiondefinition[GO:0050955]  
1
  • IDAMGI
Transportdefinition[GO:0006810]  
1
  • TASPINC
Enzymatic activity 
It is regulated in the following manner
Channel activity is activated via the interaction with PIRT and phosphatidylinositol 4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity (By similarity). The channel is sensitized by ATP binding. Repeated stimulation with capsaicin gives rise to progressively smaller responses, due to desensitization. This desensitization is triggered by the influx of calcium ions and is inhibited by elevated ATP levels. Ca(2+) and CALM displace ATP from its binding site and trigger a conformation change that leads to a closed, desensitized channel. Intracellular PIP2 inhibits desensitization. The double-knot toxin (DkTx) from the Chinese earth tiger tarantula activates the channel and traps it in an open conformation (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+7442  
According to Reactome, this protein belongs to the following pathway:
TRP channels  REACT_169333  
Note 
Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TRPV1
GenomeRNAi: 7442
PRO: PR:Q8NER1
Chemistry
GuidetoPHARMACOLOGY: 507