ACVR1C - Activin receptor type-1C - human protein (Function)
 
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ACVR1C »  Activin receptor type-1C   [ EC 2.7.11.30 ]
 
Protein also known as:  Activin receptor-like kinase 7 (ALK-7).
Gene name:  ACVR1C
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 4
GENE REF ISO

Function

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Overview 
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.  
2
  • CuratedUniProtKB
GO molecular function 
Activin receptor activity, type Idefinition[GO:0016361]  
1
  • IDAUniProtKB
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Growth factor bindingdefinition[GO:0019838]  
1
  • IPIUniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • ICUniProtKB
Nodal bindingdefinition[GO:0038100]  
1
  • IMPBHF-UCL
Transforming growth factor beta-activated receptor activitydefinition[GO:0005024] silver  
  • IEAInterPro 2 GO
GO biological process 
Apoptotic nuclear changesdefinition[GO:0030262]  
1
  • IDAUniProtKB
Cell differentiationdefinition[GO:0030154]  
1
  • IDAUniProtKB
Lipid storagedefinition[GO:0019915] silver  
  • IEAOrtholog Compara
Negative regulation of chorionic trophoblast cell proliferationdefinition[GO:1901383]  
1
  • IMPBHF-UCL
Negative regulation of insulin secretiondefinition[GO:0046676] silver  
  • IEAOrtholog Compara
Negative regulation of trophoblast cell migrationdefinition[GO:1901164]  
1
  • IDABHF-UCL
Nodal signaling pathwaydefinition[GO:0038092]  
1
  • IMPBHF-UCL
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043280]  
1
  • IMPBHF-UCL
Protein phosphorylationdefinition[GO:0006468]  
1
  • ICUniProtKB
Response to dietary excessdefinition[GO:0002021] silver  
  • IEAOrtholog Compara
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.30: ATP + [receptor-protein] ADP + [receptor-protein] phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium or manganese.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
TGF-beta signaling pathway  hsa04350+130399  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACVR1C
GenomeRNAi: 130399
PRO: PR:Q8NER5