ATP6V1C2 - V-type proton ATPase subunit C 2 - human protein (Function)
 
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ATP6V1C2 »  V-type proton ATPase subunit C 2  (V-ATPase subunit C 2)
 
Protein also known as:  Vacuolar proton pump subunit C 2.
Gene name:  ATP6V1C2
Family name: V-ATPase C subunit
Entry whose protein(s) existence is based on evidence at transcript level
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1 14 2
GENE REF ISO

Function

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Overview 
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily  3.A.2.2.4  
GO molecular function 
Hydrogen-exporting ATPase activity, phosphorylative mechanismdefinition[GO:0008553] silver  
  • IEAOrtholog Compara
GO biological process 
ATP hydrolysis coupled proton transportdefinition[GO:0015991] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Collecting duct acid secretion  hsa04966+245973  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+245973  
Metabolic pathways  hsa01100+245973  
Oxidative phosphorylation  hsa00190+245973  
Phagosome  hsa04145+245973  
Rheumatoid arthritis  hsa05323+245973  
Synaptic vesicle cycle  hsa04721+245973  
Vibrio cholerae infection  hsa05110+245973  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Signal Transduction  REACT_111102  
Transmembrane transport of small molecules  REACT_15518  
 
More information is available from:
 

Keywords

Biological process 
Hydrogen ion transport  definition   [KW-0375]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP6V1C2
GenomeRNAi: 245973
PRO: PR:Q8NEY4