DOCK8 - Dedicator of cytokinesis protein 8 - human protein (Function)
 
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DOCK8 »  Dedicator of cytokinesis protein 8
 
Gene name:  DOCK8
Family name: DOCK
Entry whose protein(s) existence is based on evidence at protein level
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1 61 4
GENE REF ISO

Function

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Overview 
Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Guanyl-nucleotide exchange factor activitydefinition[GO:0005085]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Memory T cell proliferationdefinition[GO:0061485]  
1
  • IMPMGI
Small GTPase mediated signal transductiondefinition[GO:0007264] silver  
  • IEAInterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Dock8
GenomeRNAi: 81704
PRO: PR:Q8NF50