FLCN - Folliculin - human protein (Function)
 
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FLCN »  Folliculin
 
Protein also known as:  BHD skin lesion fibrofolliculoma protein.
Gene name:  FLCN
Family name: Folliculin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 75 3
GENE REF ISO

Function

 show evidences
Overview 
May play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). May be a tumor suppressor. May be involved in colorectal tumorigenesis. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.  
3
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
Protein complex bindingdefinition[GO:0032403]  
1
  • IDAUniProtKB
GO biological process 
Cell-cell junction assemblydefinition[GO:0007043]  
  • ISSOrtholog Curator
Hemopoiesisdefinition[GO:0030097]  
  • ISSOrtholog Curator
In utero embryonic developmentdefinition[GO:0001701]  
  • ISSOrtholog Curator
Negative regulation of ATP biosynthetic processdefinition[GO:2001170]  
  • ISSOrtholog Curator
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IDAUniProtKB
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • IMPUniProtKB
Negative regulation of cell proliferation involved in kidney developmentdefinition[GO:1901723]  
  • ISSOrtholog Curator
Negative regulation of energy homeostasisdefinition[GO:2000506]  
  • ISSOrtholog Curator
Negative regulation of ERK1 and ERK2 cascadedefinition[GO:0070373]  
  • ISSOrtholog Curator
Negative regulation of gene expressiondefinition[GO:0010629]  
  • ISSOrtholog Curator
Negative regulation of mitochondrion organizationdefinition[GO:0010823]  
  • ISSOrtholog Curator
Negative regulation of protein kinase B signalingdefinition[GO:0051898]  
  • ISSOrtholog Curator
Negative regulation of protein localization to nucleusdefinition[GO:1900181]  
1
  • IDAUniProtKB
Negative regulation of Rho protein signal transductiondefinition[GO:0035024]  
1
  • IMPUniProtKB
Negative regulation of TOR signalingdefinition[GO:0032007]  
  • ISSOrtholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
2
  • IMPUniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065]  
  • ISSOrtholog Curator
Positive regulation of cell adhesiondefinition[GO:0045785]  
1
  • IMPUniProtKB
Positive regulation of gene expressiondefinition[GO:0010628]  
  • ISSOrtholog Curator
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
  • ISSOrtholog Curator
Positive regulation of TOR signalingdefinition[GO:0032008]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IMPUniProtKB
Positive regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0030511]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Regulation of cytokinesisdefinition[GO:0032465]  
1
  • IMPUniProtKB
Regulation of histone acetylationdefinition[GO:0035065]  
  • ISSOrtholog Curator
Regulation of pro-B cell differentiationdefinition[GO:2000973]  
  • ISSOrtholog Curator
Regulation of protein phosphorylationdefinition[GO:0001932]  
1
  • IDAUniProtKB
Regulation of TOR signalingdefinition[GO:0032006]  
  • ISSOrtholog Curator
TOR signalingdefinition[GO:0031929]  
1
  • IMPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Renal cell carcinoma  hsa05211+201163  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Folliculin
GenomeRNAi: 201163
PRO: PR:Q8NFG4