BHLHE22 - Class E basic helix-loop-helix protein 22 - human protein (Function)
 
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Protein
Gene
References

 
BHLHE22 »  Class E basic helix-loop-helix protein 22  (bHLHe22)
 
Protein also known as:  Trinucleotide repeat-containing gene 20 protein.
Gene name:  BHLHE22
Entry whose protein(s) existence is based on evidence at transcript level
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GENE REF ISO

Function

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Overview 
Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity).  
1
  • UniProtKB
GO molecular function 
Protein dimerization activitydefinition[GO:0046983] silver  
1
  • InterPro 2 GO
RNA polymerase II transcription factor activity, sequence-specific DNA bindingdefinition[GO:0000981] silver  
1
  • InterPro 2 GO
GO biological process 
Neurogenesisdefinition[GO:0022008] silver  
1
  • InterPro 2 GO
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • InterPro 2 GO
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 27319
PRO: PR:Q8NFJ8