BHLHE22 - Class E basic helix-loop-helix protein 22 - human protein (Function)
 
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Protein
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References

 
BHLHE22 »  Class E basic helix-loop-helix protein 22  (bHLHe22)
 
Protein also known as:  Trinucleotide repeat-containing gene 20 protein.
Gene name:  BHLHE22
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981] silver  
  • IEAOrtholog Compara
GO biological process 
Anterior commissure morphogenesisdefinition[GO:0021960] silver  
  • IEAOrtholog Compara
Cerebral cortex regionalizationdefinition[GO:0021796] silver  
  • IEAOrtholog Compara
Corpus callosum morphogenesisdefinition[GO:0021540] silver  
  • IEAOrtholog Compara
Corticospinal tract morphogenesisdefinition[GO:0021957] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892] silver  
  • IEAOrtholog Compara
Retinal bipolar neuron differentiationdefinition[GO:0060040] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 27319
PRO: PR:Q8NFJ8