ADCY4 - Adenylate cyclase type 4 - human protein (Function)
 
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Gene
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ADCY4 »  Adenylate cyclase type 4   [ EC 4.6.1.1 ]
 
Protein also known as:  ATP pyrophosphate-lyase 4.
Gene name:  ADCY4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.  
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  • UniProtKB
GO molecular function 
Adenylate cyclase activitydefinition[GO:0004016]  
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  • Ortholog Curator
  • RefGenome
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
G-protein beta/gamma-subunit complex bindingdefinition[GO:0031683] silver  
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  • Ortholog Compara
Metal ion bindingdefinition[GO:0046872]  
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  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
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  • IntAct
  • UniProtKB
GO biological process 
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
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  • Ortholog Curator
cAMP biosynthetic processdefinition[GO:0006171]  
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  • RefGenome
  • Ortholog Curator
cAMP-mediated signalingdefinition[GO:0019933]  
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  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.1: ATP 3',5'-cyclic AMP + diphosphate.  
2
  • UniProtKB
It requires the following cofactor
 Mg(2+) : Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).  
3
  • UniProtKB
It is regulated in the following manner
Activated by forskolin. Insensitive to calcium/calmodulin. Stimulated by GNAS and by the G-protein beta and gamma subunit complex.  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+196883  
Calcium signaling pathway  hsa04020+196883  
Chemokine signaling pathway  hsa04062+196883  
Cholinergic synapse  hsa04725+196883  
Dilated cardiomyopathy  hsa05414+196883  
GABAergic synapse  hsa04727+196883  
Gap junction  hsa04540+196883  
Gastric acid secretion  hsa04971+196883  
Glutamatergic synapse  hsa04724+196883  
GnRH signaling pathway  hsa04912+196883  
HTLV-I infection  hsa05166+196883  
Melanogenesis  hsa04916+196883  
Oocyte meiosis  hsa04114+196883  
Pancreatic secretion  hsa04972+196883  
Progesterone-mediated oocyte maturation  hsa04914+196883  
Purine metabolism  hsa00230+196883  
Salivary secretion  hsa04970+196883  
Taste transduction  hsa04742+196883  
Vascular smooth muscle contraction  hsa04270+196883  
According to Reactome, this protein belongs to the following pathways:
Adenylate cyclase activating pathway  R-HSA-170660  
Adenylate cyclase inhibitory pathway  R-HSA-170670  
G alpha (i) signalling events  R-HSA-418594  
G alpha (s) signalling events  R-HSA-418555  
G alpha (z) signalling events  R-HSA-418597  
Glucagon signaling in metabolic regulation  R-HSA-163359  
Hedgehog 'off' state  R-HSA-5610787  
PKA activation  R-HSA-163615  
PKA activation in glucagon signalling  R-HSA-164378  
Vasopressin regulates renal water homeostasis via Aquaporins  R-HSA-432040  
 

Keywords

Biological process 
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADCY4
GenomeRNAi: 196883
PRO: PR:Q8NFM4