ADCY4 - Adenylate cyclase type 4 - human protein (Function)
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ADCY4 »  Adenylate cyclase type 4   [ EC ]
Protein also known as:  ATP pyrophosphate-lyase 4.
Gene name:  ADCY4
Entry whose protein(s) existence is based on evidence at protein level
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This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Adenylate cyclase activitydefinition[GO:0004016]  
  • ISSOrtholog Curator
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
  • IPIUniProtKB
GO biological process 
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
  • ISSOrtholog Curator
cAMP biosynthetic processdefinition[GO:0006171]  
  • ISSOrtholog Curator
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC ATP 3',5'-cyclic AMP + diphosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 magnesium ions per subunit (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex (By similarity).  
  • CuratedUniProtKB
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+196883  
Calcium signaling pathway  hsa04020+196883  
Chemokine signaling pathway  hsa04062+196883  
Cholinergic synapse  hsa04725+196883  
Dilated cardiomyopathy  hsa05414+196883  
GABAergic synapse  hsa04727+196883  
Gap junction  hsa04540+196883  
Gastric acid secretion  hsa04971+196883  
Glutamatergic synapse  hsa04724+196883  
GnRH signaling pathway  hsa04912+196883  
HTLV-I infection  hsa05166+196883  
Melanogenesis  hsa04916+196883  
Oocyte meiosis  hsa04114+196883  
Pancreatic secretion  hsa04972+196883  
Progesterone-mediated oocyte maturation  hsa04914+196883  
Purine metabolism  hsa00230+196883  
Salivary secretion  hsa04970+196883  
Taste transduction  hsa04742+196883  
Vascular smooth muscle contraction  hsa04270+196883  
According to Reactome, this protein belongs to the following pathways:
Adenylate cyclase activating pathway  REACT_15312  
Adenylate cyclase inhibitory pathway  REACT_15333  
G alpha (i) signalling events  REACT_19231  
G alpha (s) signalling events  REACT_19327  
G alpha (z) signalling events  REACT_19333  
Glucagon signaling in metabolic regulation  REACT_1665  
PKA activation  REACT_15530  
PKA activation in glucagon signalling  REACT_1946  
Regulation of water balance by renal Aquaporins  REACT_24023  


Biological process 
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: ADCY4
GenomeRNAi: 196883