BEST2 - Bestrophin-2 - human protein (Function)
 
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Protein
Gene
References

 
BEST2 »  Bestrophin-2
 
Protein also known as:  Vitelliform macular dystrophy 2-like protein 1.
Gene name:  BEST2
Family name: Bestrophin
Entry whose protein(s) existence is based on evidence at protein level
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1 17 1
GENE REF ISO

Function

 show evidences
Overview 
Forms calcium-sensitive chloride channels. Permeable to bicarbonate.  
3
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the anion channel-forming bestrophin (bestrophin) family  1.A.46.1.2  
GO molecular function 
Contributes to chloride channel activitydefinition[GO:0005254]  
  • ISSOrtholog Curator
GO biological process 
Chloride transmembrane transportdefinition[GO:1902476]  
  • IEAOrtholog Compara
  • IEAUniProtKB KW
  • ISSOrtholog Curator
Membrane depolarizationdefinition[GO:0051899]  
  • ISSOrtholog Curator
Sensory perception of smelldefinition[GO:0007608]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Salivary secretion  hsa04970+54831  
According to Reactome, this protein belongs to the following pathway:
Stimuli-sensing channels  REACT_160189  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BEST2
GenomeRNAi: 54831
PRO: PR:Q8NFU1