DMBX1 - Diencephalon/mesencephalon homeobox protein 1 - human protein (Function)
 
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Protein
Gene
References

 
DMBX1 »  Diencephalon/mesencephalon homeobox protein 1
 
Protein also known as:  Paired-like homeobox protein DMBX1.
Gene name:  DMBX1
Family name: Paired homeobox
Entry whose protein(s) existence is based on evidence at protein level
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1 12 2
GENE REF ISO

Function

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Overview 
Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development (By similarity).  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • ISSOrtholog Curator
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565]  
  • ISSOrtholog Curator
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
  • ISSOrtholog Curator
GO biological process 
Adult feeding behaviordefinition[GO:0008343] silver  
  • IEAOrtholog Compara
Adult locomotory behaviordefinition[GO:0008344] silver  
  • IEAOrtholog Compara
Brain developmentdefinition[GO:0007420]  
  • ISSOrtholog Curator
Central nervous system developmentdefinition[GO:0007417]  
  • ISSOrtholog Curator
Developmental growthdefinition[GO:0048589]  
  • ISSOrtholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 127343
PRO: PR:Q8NFW5