FBXO18 - F-box DNA helicase 1 - human protein (Function)
 
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FBXO18 »  F-box DNA helicase 1   [ EC 3.6.4.12 ]
 
Protein also known as:  F-box only protein 18.
Gene name:  FBXO18
Family name: Helicase » UvrD
Entry whose protein(s) existence is based on evidence at protein level
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1 46 2
GENE REF ISO

Function

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Overview 
3'-5' DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed17724085, PubMed19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed23319600, PubMed23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed25585578).  
8
  • UniProtKB
GO molecular function 
3'-5' DNA helicase activitydefinition[GO:0043138]  
2
  • UniProtKB
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
ATP-dependent DNA helicase activitydefinition[GO:0004003] silver  
1
  • InterPro 2 GO
DNA helicase activitydefinition[GO:0003678]  
2
  • UniProtKB
DNA translocase activitydefinition[GO:0015616]  
1
  • MGI
Double-stranded DNA bindingdefinition[GO:0003690]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • UniProtKB
  • IntAct
Single-stranded DNA bindingdefinition[GO:0003697]  
2
  • UniProtKB
GO biological process 
Cell deathdefinition[GO:0008219]  
2
  • UniProtKB
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
4
  • UniProtKB
DNA catabolic process, endonucleolyticdefinition[GO:0000737]  
1
  • MGI
DNA duplex unwindingdefinition[GO:0032508]  
5
  • GOC
  • InterPro 2 GO
Double-strand break repair via homologous recombinationdefinition[GO:0000724]  
1
  • Ortholog Curator
Negative regulation of chromatin bindingdefinition[GO:0035562] silver  
1
  • Ortholog Compara
Negative regulation of double-strand break repair via homologous recombinationdefinition[GO:2000042]  
1
  • UniProtKB
Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:1902231]  
1
  • MGI
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • MGI
Protein ubiquitinationdefinition[GO:0016567]  
2
  • UniProtKB
  • UniPathway
Replication fork processingdefinition[GO:0031297]  
1
  • UniProtKB
Replication fork protectiondefinition[GO:0048478]  
1
  • Ortholog Curator
Response to intra-S DNA damage checkpoint signalingdefinition[GO:0072429]  
1
  • MGI
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.12: ATP + H(2)O ADP + phosphate.  
3
  • UniProtKB
Pathways 
This protein is involved in the following pathway
Protein modification; protein ubiquitination  
2
  • UniProtKB
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 84893
PRO: PR:Q8NFZ0