FBXO18 - F-box only protein 18 - human protein (Function)
 
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Protein
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References

 
FBXO18 »  F-box only protein 18   [ EC 3.6.4.12 ]
 
Protein also known as:  F-box DNA helicase 1.
Gene name:  FBXO18
Family name: Helicase » UvrD
Entry whose protein(s) existence is based on evidence at protein level
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1 30 2
GENE REF ISO

Function

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Overview 
DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction.  
1
  • CuratedUniProtKB
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATP-dependent DNA helicase activitydefinition[GO:0004003] silver  
  • IEAInterPro 2 GO
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.12: ATP + H(2)O ADP + phosphate.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 84893
PRO: PR:Q8NFZ0