CASC5 - Protein CASC5 - human protein (Function)
 
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Protein
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CASC5 »  Protein CASC5
 
Protein also known as:  Cancer susceptibility candidate gene 5 protein.
Gene name:  CASC5
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.  
3
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Acrosome assemblydefinition[GO:0001675]  
1
  • NASUniProtKB
Attachment of spindle microtubules to kinetochoredefinition[GO:0008608]  
1
  • IDAUniProtKB
Mitosisdefinition[GO:0007067]  
  • IEAUniProtKB KW
Negative regulation of phosphatase activitydefinition[GO:0010923]  
1
  • IDAUniProtKB
Protein localization to kinetochoredefinition[GO:0034501]  
1
  • IDAMGI
Spindle assembly checkpointdefinition[GO:0071173]  
1
  • IDAUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Mitotic M-M/G1 phases  REACT_21300  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Chromosome partition  definition   [KW-0159]
Mitosis  definition   [KW-0498]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CASC5
GenomeRNAi: 57082
PRO: PR:Q8NG31