CASC5 - Protein CASC5 - human protein (Function)
 
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Protein
Gene
References

 
CASC5 »  Protein CASC5
 
Protein also known as:  Cancer susceptibility candidate gene 5 protein.
Gene name:  CASC5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.  
4
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
GO biological process 
Acrosome assemblydefinition[GO:0001675]  
1
  • UniProtKB
Attachment of spindle microtubules to kinetochoredefinition[GO:0008608]  
1
  • UniProtKB
Cell divisiondefinition[GO:0051301]  
1
  • UniProtKB KW
Mitotic nuclear divisiondefinition[GO:0007067]  
1
  • UniProtKB KW
Negative regulation of phosphatase activitydefinition[GO:0010923]  
1
  • UniProtKB
Protein localization to kinetochoredefinition[GO:0034501]  
1
  • MGI
Spindle assembly checkpointdefinition[GO:0071173]  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Deposition of new CENPA-containing nucleosomes at the centromere  R-HSA-606279  
Mitotic Prometaphase  R-HSA-68877  
Resolution of Sister Chromatid Cohesion  R-HSA-2500257  
RHO GTPases Activate Formins  R-HSA-5663220  
Separation of Sister Chromatids  R-HSA-2467813  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Chromosome partition  definition   [KW-0159]
Mitosis  definition   [KW-0498]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CASC5
GenomeRNAi: 57082
PRO: PR:Q8NG31