NEK11 - Serine/threonine-protein kinase Nek11 - human protein (Function)
 
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NEK11 »  Serine/threonine-protein kinase Nek11   [ EC 2.7.11.1 ]
 
Protein also known as:  Never in mitosis A-related kinase 11 (NimA-related protein kinase 11).
Gene name:  NEK11
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
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  • IDAUniProtKB
GO biological process 
G2 DNA damage checkpointdefinition[GO:0031572]  
1
  • IMPUniProtKB
Intra-S DNA damage checkpointdefinition[GO:0031573]  
1
  • IDAUniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
2
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
2
  • CuratedUniProtKB
It requires the following cofactor
Manganese or magnesium.  
2
  • CuratedUniProtKB
It is regulated in the following manner
Autorepressed by intramolecular binding of the C-terminus which dissociates following phosphorylation by NEK2 isoform 1 in G1/S-arrested cells. NEK2 isoform 2 is largely not present in the nucleolus, and does not appear to phosphorylate NEK11. Activated in response to DNA damage. Inhibited by zinc.  
2
  • CuratedUniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 79858
PRO: PR:Q8NG66
Chemistry
GuidetoPHARMACOLOGY: 2116