ATP6V0E2 - V-type proton ATPase subunit e 2 - human protein (Function)
 
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ATP6V0E2 »  V-type proton ATPase subunit e 2  (V-ATPase subunit e 2)
 
Protein also known as:  Lysosomal 9 kDa H(+)-transporting ATPase V0 subunit e2.
Gene name:  ATP6V0E2
Family name: V-ATPase e1/e2 subunit
Entry whose protein(s) existence is based on evidence at transcript level
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1 6 4
GENE REF ISO

Function

 show evidences
Overview 
Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATPase activity, coupled to transmembrane movement of ionsdefinition[GO:0042625]  
  • ISSOrtholog Curator
Hydrogen ion transmembrane transporter activitydefinition[GO:0015078] silver  
  • IEAInterPro 2 GO
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
  • ISSOrtholog Curator
ATP hydrolysis coupled proton transportdefinition[GO:0015991] silver  
  • IEAInterPro 2 GO
Cell growthdefinition[GO:0016049]  
1
  • IGIUniProtKB
Metabolic processdefinition[GO:0008152]  
  • ISSOrtholog Curator
Vacuolar acidificationdefinition[GO:0007035]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Collecting duct acid secretion  hsa04966+155066  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+155066  
Metabolic pathways  hsa01100+155066  
Oxidative phosphorylation  hsa00190+155066  
Phagosome  hsa04145+155066  
Rheumatoid arthritis  hsa05323+155066  
Synaptic vesicle cycle  hsa04721+155066  
Vibrio cholerae infection  hsa05110+155066  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Signal Transduction  REACT_111102  
Transmembrane transport of small molecules  REACT_15518  
 
More information is available from:
 

Keywords

Biological process 
Hydrogen ion transport  definition   [KW-0375]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 155066
PRO: PR:Q8NHE4