TPCN2 - Two pore calcium channel protein 2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
TPCN2 »  Two pore calcium channel protein 2
 
Protein also known as:  Voltage-dependent calcium channel protein TPC2.
Gene name:  TPCN2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 24 1
GENE REF ISO

Function

 show evidences
Overview 
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.11.19  
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
NAADP-sensitive calcium-release channel activitydefinition[GO:0072345]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
Voltage-gated calcium channel activitydefinition[GO:0005245]  
  • IBARefGenome
  • ISSOrtholog Curator
GO biological process 
Calcium ion transportdefinition[GO:0006816] silver  
  • IBARefGenome
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • IDAUniProtKB
Ion transmembrane transportdefinition[GO:0034220] silver  
  • IBARefGenome
Membrane depolarization during action potentialdefinition[GO:0086010] silver  
  • IBARefGenome
Release of sequestered calcium ion into cytosoldefinition[GO:0051209] silver  
  • IEAOrtholog Compara
Smooth muscle contractiondefinition[GO:0006939]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Pancreatic secretion  hsa04972+219931  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TPCN2
GenomeRNAi: 219931
PRO: PR:Q8NHX9