ADCK3 - Atypical kinase ADCK3, mitochondrial - human protein (Function)
 
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ADCK3 »  Atypical kinase ADCK3, mitochondrial   [ EC 2.7.-.- ]
 
Protein also known as:  aarF domain-containing protein kinase 3.
Gene name:  ADCK3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed25498144). Its substrate specificity is unclear: either acts as protein kinase that phosphorylates other proteins in the CoQ complex to stabilize their interactions or acts as a small molecule kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway (PubMed25498144). Shows an unusual selectivity for binding ADP over ATP (PubMed25498144).  
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  • UniProtKB
GO molecular function 
ADP bindingdefinition[GO:0043531]  
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  • UniProtKB
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Kinase activitydefinition[GO:0016301]  
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  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
GO biological process 
Phosphorylationdefinition[GO:0016310]  
1
  • UniProtKB
Ubiquinone biosynthetic processdefinition[GO:0006744]  
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  • UniProtKB
  • UniPathway
Enzymatic activity 
It is regulated in the following manner
Autoinhibited by the N-terminal domain, containing the KxGQ motif, that completely occludes the typical substrate binding pocket.  
2
  • UniProtKB
Pathways 
This protein is involved in the following pathway
Cofactor biosynthesis; ubiquinone biosynthesis  
2
  • UniProtKB
 

Keywords

Biological process 
Ubiquinone biosynthesis  definition   [KW-0831]
Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CABC1
GenomeRNAi: 56997
PRO: PR:Q8NI60
Chemistry
GuidetoPHARMACOLOGY: 1927