GRPEL2 - GrpE protein homolog 2, mitochondrial - human protein (Function)
 
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Protein
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References

 
GRPEL2 »  GrpE protein homolog 2, mitochondrial
 
Gene name:  GRPEL2
Family name: GrpE
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Adenyl-nucleotide exchange factor activitydefinition[GO:0000774] silver  
  • IEAInterPro 2 GO
Chaperone bindingdefinition[GO:0051087] silver  
  • IEAInterPro 2 GO
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAInterPro 2 GO
Unfolded protein bindingdefinition[GO:0051082] silver  
  • IEAOrtholog Compara
GO biological process 
Protein foldingdefinition[GO:0006457] silver  
  • IEAInterPro 2 GO
Regulation of catalytic activitydefinition[GO:0050790]  
  • IEAInterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathway:
Mitochondrial protein import  REACT_118595  
 

Keywords

Molecular function 
Chaperone  definition   [KW-0143]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 134266
PRO: PR:Q8TAA5