GADD45GIP1 - Growth arrest and DNA damage-inducible proteins-interacting protein 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
GADD45GIP1 »  Growth arrest and DNA damage-inducible proteins-interacting protein 1
 
Protein also known as:  Papillomavirus L2-interacting nuclear protein 1 (PLINP).
Gene name:  GADD45GIP1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 22 1
GENE REF ISO

Function

 show evidences
Overview 
Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
Cell cycledefinition[GO:0007049]  
  • IEAUniProtKB KW
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Note 
Cells overexpressing GADD45GIP1 were more likely to be in G1 and less likely to be in S phase and grow more slowly than control cells. Inhibiting the expression of GADD45GIP1 promotes cell cycle progression.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GADD45GIP1
GenomeRNAi: 90480
PRO: PR:Q8TAE8