ABHD4 - Abhydrolase domain-containing protein 4 - human protein (Function)
 
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ABHD4 »  Abhydrolase domain-containing protein 4
 
Gene name:  ABHD4
Family name: Peptidase S33 » ABHD4/ABHD5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Hydrolase activitydefinition[GO:0016787]  
  • IEAUniProtKB KW
GO biological process 
Lipid catabolic processdefinition[GO:0016042]  
  • IEAUniProtKB KW
Enzymatic activity 
 
More information is available from:
Caution 
Thr-291 is present instead of the conserved His which is expected to be an active site residue.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 63874
PRO: PR:Q8TB40