ETNPPL - Ethanolamine-phosphate phospho-lyase - human protein (Function)
 
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Protein
Gene
References

 
ETNPPL »  Ethanolamine-phosphate phospho-lyase   [ EC 4.2.3.2 ]
 
Protein also known as:  Alanine--glyoxylate aminotransferase 2-like 1.
Gene name:  ETNPPL
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 6 3
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde.  
2
  • UniProtKB
GO molecular function 
Ethanolamine-phosphate phospho-lyase activitydefinition[GO:0050459]  
1
  • EC 2 GO
Pyridoxal phosphate bindingdefinition[GO:0030170] silver  
1
  • InterPro 2 GO
Transaminase activitydefinition[GO:0008483]  
1
  • UniProtKB KW
GO biological process 
Metabolic processdefinition[GO:0008152]  
3
  • EC 2 GO
  • UniProtKB KW
  • InterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.3.2: Ethanolamine phosphate + H(2)O acetaldehyde + NH(3) + phosphate.  
2
  • UniProtKB
It requires the following cofactor
 pyridoxal 5'-phosphate  
2
  • UniProtKB
Caution 
Does not seem to possess aminotransferase activity.  
2
  • UniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 680 uM for phosphoethanolamine (at pH 7.4)
Vmax 1.46 umol/min/mg enzyme (at pH 7.4)

Keywords

Molecular function 
Aminotransferase  definition   [KW-0032]
Lyase  definition   [KW-0456]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 64850
PRO: PR:Q8TBG4