PI4K2B - Phosphatidylinositol 4-kinase type 2-beta - human protein (Function)
 
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PI4K2B »  Phosphatidylinositol 4-kinase type 2-beta   [ EC 2.7.1.67 ]
 
Protein also known as:  Phosphatidylinositol 4-kinase type II-beta (PI4KII-BETA).
Gene name:  PI4K2B
Family name: PI3/PI4-kinase » Type II PI4K
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.  
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  • CuratedUniProtKB
GO molecular function 
1-phosphatidylinositol 4-kinase activitydefinition[GO:0004430]  
  • IEAEC 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
GO biological process 
Phosphatidylinositol phosphorylationdefinition[GO:0046854]  
  • IEAEC 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.1.67: ATP + 1-phosphatidyl-1D-myo-inositol ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.  
  • CuratedUniProtKB
It is regulated in the following manner
Recruited and activated by membrane association. Binding to the microsomal membrane has been shown to enhance its activity.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Inositol phosphate metabolism  hsa00562+55300  
Metabolic pathways  hsa01100+55300  
Phosphatidylinositol signaling system  hsa04070+55300  
According to Reactome, this protein belongs to the following pathways:
Synthesis of PIPs at the early endosome membrane  REACT_120756  
Synthesis of PIPs at the ER membrane  REACT_121168  
Synthesis of PIPs at the Golgi membrane  REACT_120836  
Synthesis of PIPs at the plasma membrane  REACT_121025  
 
More information is available from:
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PI4K2B
GenomeRNAi: 55300
PRO: PR:Q8TCG2
Chemistry
GuidetoPHARMACOLOGY: 2499