SPPL3 - Signal peptide peptidase-like 3 - human protein (Function)
 
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SPPL3 »  Signal peptide peptidase-like 3   [ EC 3.4.23.- ]  (SPP-like 3)
 
Protein also known as:  Presenilin homologous protein 1 (PSH1).
Gene name:  SPPL3
Family name: Peptidase A22B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.  
1
  • CuratedUniProtKB
GO molecular function 
Aspartic endopeptidase activity, intramembrane cleavingdefinition[GO:0042500]  
1
  • IMPUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
3
  • IDAUniProtKB
GO biological process 
Not  Membrane protein ectodomain proteolysisdefinition[GO:0006509]  
2
  • IMPUniProtKB
Enzymatic activity 
It is regulated in the following manner
Its proteolytic activity is blocked by signal peptide peptidase (SPP) inhibitors.  
1
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: UNQ1887
GenomeRNAi: 121665
PRO: PR:Q8TCT6