SPPL2B - Signal peptide peptidase-like 2B - human protein (Function)
 
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SPPL2B »  Signal peptide peptidase-like 2B
 
Gene name:  SPPL2B
Family name: Peptidase A22B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity.  
5
  • CuratedUniProtKB
GO molecular function 
Contradiction  Aspartic endopeptidase activity, intramembrane cleavingdefinition[GO:0042500]  
3
  • IMPUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
3
  • IDAUniProtKB
GO biological process 
Membrane protein ectodomain proteolysisdefinition[GO:0006509]  
2
  • IDAUniProtKB
Membrane protein intracellular domain proteolysisdefinition[GO:0031293]  
4
  • IMPUniProtKB
Regulation of immune responsedefinition[GO:0050776]  
1
  • IMPUniProtKB
Enzymatic activity 
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SPPL2B
GenomeRNAi: 56928
PRO: PR:Q8TCT7