SPPL2A - Signal peptide peptidase-like 2A - human protein (Function)
 
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SPPL2A »  Signal peptide peptidase-like 2A
 
Gene name:  SPPL2A
Family name: Peptidase A22B
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity.  
4
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the presenilin er ca(2+) leak channel (presenilin) family  1.A.54.3.2  
GO molecular function 
Aspartic-type endopeptidase activitydefinition[GO:0004190] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
GO biological process 
Membrane protein ectodomain proteolysisdefinition[GO:0006509]  
2
  • IDAUniProtKB
Membrane protein intracellular domain proteolysisdefinition[GO:0031293]  
3
  • IDAUniProtKB
Regulation of immune responsedefinition[GO:0050776]  
1
  • IMPUniProtKB
Enzymatic activity 
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SPPL2A
GenomeRNAi: 84888
PRO: PR:Q8TCT8