HM13 - Minor histocompatibility antigen H13 - human protein (Function)
 
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HM13 »  Minor histocompatibility antigen H13   [ EC 3.4.23.- ]
 
Protein also known as:  Presenilin-like protein 3.
Gene name:  HM13
Family name: Peptidase A22B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection (By similarity). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed11714810, PubMed12077416, PubMed12145199, PubMed14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed25239945).  
6
  • UniProtKB
GO molecular function 
Aspartic endopeptidase activity, intramembrane cleavingdefinition[GO:0042500]  
2
  • UniProtKB
Peptidase activitydefinition[GO:0008233]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
3
  • UniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • UniProtKB
GO biological process 
Not  Membrane protein ectodomain proteolysisdefinition[GO:0006509]  
1
  • UniProtKB
Not  Membrane protein intracellular domain proteolysisdefinition[GO:0031293]  
1
  • UniProtKB
Membrane protein proteolysisdefinition[GO:0033619]  
1
  • UniProtKB
Enzymatic activity 
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HM13
GenomeRNAi: 81502
PRO: PR:Q8TCT9