HM13 - Minor histocompatibility antigen H13 - human protein (Function)
 
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HM13 »  Minor histocompatibility antigen H13   [ EC 3.4.23.- ]
 
Protein also known as:  Presenilin-like protein 3.
Gene name:  HM13
Family name: Peptidase A22B
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 4
GENE REF ISO

Function

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Overview 
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection (By similarity). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1.  
4
  • CuratedUniProtKB
GO molecular function 
Aspartic endopeptidase activity, intramembrane cleavingdefinition[GO:0042500]  
1
  • IMPUniProtKB
Peptidase activitydefinition[GO:0008233]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
3
  • IDAUniProtKB
GO biological process 
Not  Membrane protein ectodomain proteolysisdefinition[GO:0006509]  
1
  • IMPUniProtKB
Not  Membrane protein intracellular domain proteolysisdefinition[GO:0031293]  
1
  • IMPUniProtKB
Membrane protein proteolysisdefinition[GO:0033619]  
1
  • IDAUniProtKB
Enzymatic activity 
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HM13
GenomeRNAi: 81502
PRO: PR:Q8TCT9