GRIN3A - Glutamate receptor ionotropic, NMDA 3A - human protein (Function)
 
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GRIN3A »  Glutamate receptor ionotropic, NMDA 3A  (GluN3A)
 
Protein also known as:  N-methyl-D-aspartate receptor subtype 3A (NR3A).
Gene name:  GRIN3A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).  
1
  • UniProtKB
GO molecular function 
Calcium channel activitydefinition[GO:0005262] silver  
1
  • Ortholog Compara
Extracellular-glutamate-gated ion channel activitydefinition[GO:0005234]  
1
  • RefGenome
Glycine bindingdefinition[GO:0016594]  
1
  • UniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • UniProtKB
Contributes to N-methyl-D-aspartate selective glutamate receptor activitydefinition[GO:0004972]  
2
  • UniProtKB
  • Ortholog Curator
Neurotransmitter bindingdefinition[GO:0042165] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
Protein phosphatase 2A bindingdefinition[GO:0051721]  
1
  • Ortholog Curator
GO biological process 
Calcium ion transmembrane transportdefinition[GO:0070588] silver  
1
  • Ortholog Compara
Calcium ion transportdefinition[GO:0006816]  
1
  • Ortholog Curator
Dendrite developmentdefinition[GO:0016358] silver  
1
  • Ortholog Compara
Ion transmembrane transportdefinition[GO:0034220]  
1
  • RefGenome
Ionotropic glutamate receptor signaling pathwaydefinition[GO:0035235]  
1
  • RefGenome
Prepulse inhibitiondefinition[GO:0060134] silver  
1
  • Ortholog Compara
Response to ethanoldefinition[GO:0045471]  
2
  • UniProtKB
Rhythmic processdefinition[GO:0048511] silver  
1
  • Ortholog Compara
Synaptic transmission, glutamatergicdefinition[GO:0035249]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glutamatergic synapse  hsa04724+116443  
Neuroactive ligand-receptor interaction  hsa04080+116443  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GRIN3A
GenomeRNAi: 116443
PRO: PR:Q8TCU5
Chemistry
GuidetoPHARMACOLOGY: 460